|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
In this study, we examined the protective effect of adeno-associated virus serotype 7 encoding MANF in a rodent model of stroke.
|
20685313 |
2010 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
The beneficial effect of MANF treatment on the reversal of stroke-induced behavioral deficits implies that MANF-based therapies could be used for the repair of brain tissue after stroke.
|
29806020 |
2018 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
Recombinant human MANF was administered intracerebroventricularly 24 h after stroke.
|
31785307 |
2020 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke.
|
29050872 |
2018 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Recent studies in rodent models have demonstrated that MANF mitigates diabetes, exerts neurotrophic function in neurodegenerative disease, protects cardiomyocytes and neurons in myocardial infarction and cerebral ischemia, respectively, and promotes immune cell phenotype switch from proinflammatory macrophages to prorepair anti-inflammatory macrophages.
|
28719799 |
2017 |
|
Diabetes Mellitus
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Furthermore, increased MANF levels has been detected in the sera of young children with newly diagnosed Type 1 (T1D) diabetes and Type 2 (T2D) diabetic patients.
|
30386256 |
2018 |
|
Neurodegenerative Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Neurodegenerative Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) form a family of atypical growth factors discovered for their neuroprotective properties in the central nervous system (CNS) in animal models of neurodegenerative diseases.
|
31781038 |
2019 |
|
Neurodegenerative Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a potent survival-promoting protein with neurorestorative effect for neurodegenerative diseases.
|
30234112 |
2018 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Of them 12 are associated with other autoimmune diseases than SLE, whereas three genes (ZNF804A, CDK1, and MANF) have not previously been associated with autoimmunity.
|
28740209 |
2017 |
|
Autoimmune Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models.
|
25640174 |
2015 |
|
Hepatitis
|
0.020 |
Biomarker
|
group |
BEFREE |
In conclusion, MANF plays an important role in linking ER stress and liver inflammation by inhibiting the NF-κB/Snail signal pathway in EMT and HCC progression.
|
31469428 |
2019 |
|
Hepatitis
|
0.020 |
AlteredExpression
|
group |
BEFREE |
These results suggested that the AP‑1 complex may be a novel regulator of MANF transcription, which may be involved in liver inflammation and fibrosis.
|
30365109 |
2018 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In addition, for the first time, we have discovered that MANF can potentially serve as a urinary ER stress biomarker in ER stress-mediated kidney disease.
|
28719799 |
2017 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Recently, we have identified mesencephalic astrocyte-derived neurotrophic factor (MANF) and cysteine-rich with EGF-like domains 2 (CRELD2) as urinary ER stress biomarkers in ER stress-mediated kidney diseases.
|
30099615 |
2019 |
|
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We have reported the presence of a specific mutation (ATG50-->AGG) or deletion of codon 50 of the ARP gene in different tumor types (Shridhar et al., 1996, 1996a).
|
9174057 |
1997 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
MANF levels were also associated with the status of liver cirrhosis, advanced Tumor-Node-Metastasis (TNM) stage and tumor size.
|
31469428 |
2019 |
|
nervous system disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
Many groups, including ours, have proved that MANF rescues neuronal loss in several neurological disorders, such as Parkinson's disease and cerebral ischemia.
|
30760285 |
2019 |
|
nervous system disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
This review focuses on MANF, summarizing its unique structure, potential signaling pathway, and role in neurological disease.
|
28685189 |
2017 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, MANF may be a cancer suppressor and a potential therapeutic target for HCC.
|
31469428 |
2019 |
|
Esophageal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues.
|
10767373 |
2000 |
|
Nephrotic Syndrome
|
0.010 |
Biomarker
|
group |
BEFREE |
K201 and MANF could be promising therapies for the treatment of podocyte ER stress-induced NS/FSGS.
|
31235574 |
2019 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Vitreous MANF may be a promising protein biomarker for the indirect assessment of retinal disorders, which could provide indirect evidence of retinal pathology.
|
28367115 |
2017 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
MANF was mainly expressed in rat neurons, and its expression increased significantly at 3 h after SAH induction and peaked at 24 h. Stereotactic injection of rh-MANF into the cerebroventricle significantly increased the level of MANF, p-Akt, p-mouse double minute 2 homolog (p-MDM2), and B-cell lymphoma 2 (Bcl-2) in brain tissue, whereas it down-regulated the expression of P53, Bcl-2-associated X protein (Bax), and cleaved caspase-3, which indicated that neuronal apoptosis was remarkably suppressed.
|
30211660 |
2019 |